| Home :: The Persistent Entity Polymorphism See AlsoSerology DescriptionThis file is a summary of the human proteins that are responsible for the molecular basis of the blood group antigens. Blood group antigens are surface markers on the outside of the red blood cell membrane. Most of them are proteins, but some are carbohydrates attached to lipids or proteins. BLOOD GROUP ANTIGEN PROTEINS | | Blood Group Carrier or Effector Protein Name system | Gene name | SWISS-PROT cross reference | Antigen names | ABO | Fucosylglycoprotein alpha-n-acetylgalactosaminyltransferase (EC 2.4.1.40) (Histo-blood group A transferase) / Fucosylglycoprotein 3-alpha-galactosyltransferase (EC 2.4.1.37) (Histo-blood group B transferase) | Gene: ABO | BGAT_HUMAN | Antigens: A/B | Chido/Rodgers | Complement C4 | Gene: C4A and C4B | CO4_HUMAN | Antigens: Ch1 to Ch6, WH, Rg1, Rg2 | Colton | Aquaporin-CHIP (Aquaporin 1). | Gene: AQP1; CHIP28 | AQP1_HUMAN | Antigens: Co(a/b | Cromer | Complement decay-accelerating factor (Antigen CD55). | Gene: DAF; CD55 | DAF_HUMAN | Antigens: Cr(a), Dr(a), Es(a), Tc(a/b/c), Wd(a), WES(a/b), IFC, UMC | Diego | Band 3 anion transport protein (Anion exchange protein 1) (AE 1). | Gene: SLC4A1; AE1;EPB3 | B3AT_HUMAN | Antigens: Di(a/b), Wr(a/b), Wd(a), Rb(a), WARR | Dombrock | Dombrock glycoprotein. | Gene: DO | Not yet identified | Antigens: Do(a/b), Gy(a), Hy, Jo(A) | Duffy | Duffy antigen (Fy glycoprotein) (Glycoprotein D) (GpFy). | Gene: FY; GPD; DARC | DUFF_HUMAN | Antigens: Fy(a/b) | Gerbich | Glycophorin C (PAS-2') (Glycoprotein beta) (Glycoconnectin) (Sialoglycoprotein D) (Glycophorin D) (GpD). | Gene: GYPC; GPC | GLPC_HUMAN | Antigens: An(a), Dh(A), Ls(a), Wb | Hh | Galactoside 2-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)Ft 1)(Fucosyltransferase 1) | Gene: FUT1 | FUT1_HUMAN | * | Hh | Galactoside 2-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)Ft 2)(Fucosyltransferase 2) (Secretor factor). | Gene: FUT2 | FUT2_HUMAN | Antigens: H/h, Se/se | I | Ii | Gene: GCNT2, IGnT | | Antigens: I/i | Indian | CD44 antigen (Phagocytic glycoprotein I) (PGP-1) (Hutch-I) (Extracellular matrix receptor-III) (ECMR-III) (Hermes antigen) (Hyaluronate receptor) (Heparan sulfate proteoglycan) (Epican). | Gene: CD44; LHR | CD44_HUMAN | Antigens: In(a/b) | Kell | Kell blood group glycoprotein (EC 3.4.24.-). | Gene: KEL | KELL_HUMAN | Antigens: K/k, Kp(a/b/c), Js(a/b), Ul(a), KEL11/17, KEL14/24 | Kidd | Urea transporter, erythrocyte. | Gene: SLC14A1; UT1; HUT11; UTE; JK; RACH1 | UT1_HUMAN | Antigens: Jk(a/b) | Knops | Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35). | Gene: CR1; C3BR | CR1_HUMAN | Antigens: Kn(a/b), McC(a), Sl(a), Yk(a) | Kx | Membrane transport protein XK (Kx antigen). | Gene: XK | XK_HUMAN | | Landsteiner-Wiener | Landsteiner-Wiener blood group glycoprotein. | Gene: LW | LW_HUMAN | Antigens: Lw(a/b) | Lewis | Galactoside 3(4)-L-fucosyltransferase (EC 2.4.1.65) (Fucosyltransferase 3) (FUCT-III). | Gene: FUT3; LE | FUT3_HUMAN | Antigens: Le(a/b) | Lutheran | Lutheran blood group glycoprotein (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) | Gene: LU; BCAM; MSK19 | LU_HUMAN | Antigens: Lu(a/b), Au(a/b), LU6 to LU20 | MNS | Glycophorin A (PAS-2) (Sialoglycoprotein alpha) (MN sialoglycoprotein). | Gene: GYPA; GPA | GLPA_HUMAN | Antigens: M/N, S/s, U, He, Mi(a), M(c), Vw, Mur, M(g), Vr, M(e), Mt(a), St(a), Ri(a), Cl(a), Ny(a), Hut, Hil, M(v), Far, Mit, Dantu, Hop, Nob, En(a), ENKT, etc. | MNS | Glycophorin B (PAS-3) (Sialoglycoprotein delta) (SS-active sialoglycoprotein). | Gene: GYPB; GPB | GLPB_HUMAN | * | P | A yet undefined galactoyltransferase. | Gene: P1 | Not yet identified | Antigens: P1 | Rh | Blood group RH(CE) polypeptide (Rhesus C/E antigens) (RHPI). | Gene: RHCE; RHC; RHE | RHCE_HUMAN | Antigens: C/c, E/e, D, f, C(e), C(w), C(x), V, E(w), G, Tar,VS, D(w), cE, etc. | Rh | Blood group RH(D) polypeptide (Rhesus D antigen)(RHPII). | Gene: RHD | RHD_HUMAN | Antigens: C/c, E/e, D, f, C(e), C(w), C(x), V, E(w), G, Tar,VS, D(w), cE, etc. | Scianna | Scianna glycoprotein. | Gene: SA | Not yet identified | Antigens: Sc(1/2), Sc3 | Xg | Xg glycoprotein (Protein PBDX) | Gene: XG; PBDX | XG_HUMAN | Antigens: Xg(a) | Yt | Acetylcholinesterase (EC 3.1.1.7). | Gene: ACHE | ACES_HUMAN | Antigens: Yt(a/b) |
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