C O N T E N T SSee AlsoDescriptionTumor Necrosis Factor (TNF) comes in two variants: alpha and beta.
GenomicsTNF tumor necrosis factor (TNF superfamily, member 2)Summary
SummaryThis gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. DiscussionOne of the main immune system Growth Factors. TNF-alpha is a critical part of the rejection process that occurs when someone is transfused with the wrong blood type.
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