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- This effect, which can be repeated many times, prolongs the duration of action of the drug until it is eventually excreted by the kidneys.
- National Rituximab is a monoclonal antibody that destroys B lymphocytes.
- This in turn reduces peripheral vascular resistance and they are used to reduce blood pressure.
- Glucagon normally has a hyperglycaemic effect.
In these cases, hormones or their synthetic analogues are used as drugs. In other cases, hormones are used as drugs in ways that differ from their physiological role.
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Bupivacaine can also be used with adrenaline. Bupivacaine is often used to produce continuous epidural anaesthesia during labour. Prilocaine is similar to lidocaine but has a longer duration of action and is less toxic.
Up until at least the age of the kidneys are not as efficient as an adults, so drug elimination may be reduced. Due to the existence of these factors, it is unsatisfactory simply to adjust doses for children because of weight alone. For the majority of drugs that have a low TR dose adjustment is best made in relation to metabolic rate, which can be estimated from body surface area. However, specialist knowledge is needed in this area.
The addition of exogenous corticosteroids to the systemic circulation is detected by the pituitary gland. In response the pituitary gland reduces its own release of adrenocorticotrophic hormone. ACTH normally stimulates the adrenal glands to release their natural corticosteroids, but with reduced levels of ACTH this does not happen.

Such latency can last for months or years. Once activated, the cell starts reading its DNA to make proteins. This includes making more viral RNA and viral proteins, which are assembled into new virus particles.
Authored by Dr. Edward E Ray, MD, FACS
