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This study used a decision analytic model approach to evaluate the cost-effectiveness of linezolid versus vancomycin in the empirical treatment of complicated skin and soft-tissue infection cSSTI due to suspected methicillin-resistant Staphylococcus aureus MRSA from the German hospital and health care system perspective. The estimated first-line cure rate for linezolid-treated patients was Linezolid was expected to result in a shorter intravenous treatment duration and shorter LOS that offset its higher acquisition cost versus vancomycin in cSSTI in Germany. Skin and soft-tissue infections SSTI are a common cause of morbidity in community settings and hospitals worldwide 1 — 3. Complications of improperly treated SSTI may result in endocarditis, osteomyelitis, meningitis and pneumonia 4.
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The study retrospectively analyzed longitudinal claims data from more than 80 health plans for patients treated with ZYVOX or vancomycin on an outpatient basis for infections of which approximately half 48 percent were skin infections. The study analyzed 1, adult patients treated with ZYVOX and 1, adult patients treated with vancomycin, matched by propensity score, between January and March In December, ZYVOX was approved for use in pediatric patients and subsequently received approval for diabetic foot infections in July To date, more than one million patients worldwide have been treated with ZYVOX for its approved indications. ZYVOX has not been studied in the treatment of decubitus ulcers.

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