20 mg lipitor

Although accumulating evidence suggests a more extensive reduction of low-density lipoprotein cholesterol LDL-C, it is unclear whether a higher statin dose is more effective and cost-effective in the Asian population. This study compared the efficacy, safety, and cost-effectiveness of atorvastatin 20 and 10 mg in high-risk Asian patients with hypercholesterolemia. The primary endpoint was the difference in the mean percentage change in LDL-C levels from baseline after 12 weeks. Cost-effectiveness was measured as an exploratory endpoint. LDL-C levels were reduced more significantly by atorvastatin 20 mg than by 10 mg after 12 weeks

In our study, we compared the short-term effects of high 80 mg vs moderate doses of atorvastatin 20 mg in patients with STEMI undergoing primary percutaneous coronary intervention on endothelial function and vascular inflammation. The aim of our study was the evaluation of dose-dependent short-term effects. Results: After 1 month of therapy, we observed differences in high-sensitivity CRP levels 0. Keywords: endothelial dysfunction, endo-PAT, vascular inflammation, acute coronary syndrome. Given the results on cardiovascular and total mortality in large clinical trials in the setting of primary and secondary prevention, statin therapy remains the cornerstone of lipid-lowering therapy. The ARMYDA-ACS 6 trial and others 7, 8 suggested that statins could reduce arterial wall mechanical injury induced by percutaneous coronary intervention PCI ; moreover, the precocity of observed clinical advantages on statin therapy led to the hypothesis that they could have a role in limiting inflammation, 9 — 12 oxidative stress, 13 and endothelial dysfunction, 14 thus contributing to plaque stabilization earlier than the mere reduction in LDL-C. In the last few years, one trial revealed that high-dose atorvastatin before primary PCI in patients presenting with STEMI was able to improve coronary flow downstream of the treated culprit vessel.

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Lipitor is indicated as an adjunct to diet for reduction of elevated total cholesterol total-C, LDL-cholesterol LDL-C, apolipoprotein B, and triglycerides in adults, adolescents and children aged 10 years or older with primary hypercholesterolaemia including familial hypercholesterolaemia heterozygous variant or combined mixed hyperlipidaemia Corresponding to Types IIa and IIb of the Fredrickson classification when response to diet and other nonpharmacological measures is inadequate. Lipitor is also indicated to reduce total-C and LDL-C in adults with homozygous familial hypercholesterolaemia as an adjunct to other lipid-lowering treatments e. LDL apheresis or if such treatments are unavailable. Prevention of cardiovascular events in adult patients estimated to have a high risk for a first cardiovascular event see section 5. The patient should be placed on a standard cholesterol-lowering diet before receiving Lipitor and should continue on this diet during treatment with Lipitor. The dose should be individualised according to baseline LDL-C levels, the goal of therapy, and patient response. The usual starting dose is 10 mg once a day. Adjustment of dose should be made at intervals of 4 weeks or more. The maximum dose is 80 mg once a day.

Pravastatin and Lipitor atorvastatin are medications that treat high cholesterol. High levels of cholesterol in the body is known to contribute to heart disease, heart attacks, and stroke. While they have similar uses, there are some differences between these medications. It is approved to decrease levels of total cholesterol, LDL cholesterol, and triglycerides. By lowering cholesterol, pravastatin helps to decrease the risk of heart attacks and stroke.

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Atorvastatin calcium trihydrate. Improved presentation of SPC uploaded. Sub-heading: Concomitant treatment with other medicinal products. Sub-heading: Musculoskeletal and connective tissue disorders. Addition of reference to section 4.

Low-density lipoprotein cholesterol LDL-C is the main target for cardiovascular risk reduction. The initial assessment included anthropometry, measuring of HbA1c and 20 mg lipitor profile standard kits Human, Germany, LDL-C was calculated using the Friedewald's equation, and oral glucose tolerance test. Survival was analysed by Kaplan-Meier's method, using Cox's F-test; Fisher's exact test or Mann-Whitney U-test were used to compare independent samples; Wilcoxon matched pairs test was used for comparison of dependent samples. Although in the end of observation, LDL-C levels in both atorvastatin regimens were significantly lower comparing to baseline 1. Therapy was associated with dose-dependent risk of T2DM. To avoid statin dose escalation, combination therapy might be considered.

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If you have high cholesterol or certain risk factors for heart disease or stroke, your doctor might prescribe Lipitor atorvastatin for you. Lipitor contains the active ingredient atorvastatin. An active ingredient is what makes a drug work. Atorvastatin is also available as a generic drug. Lipitor comes as a tablet that you swallow, and you usually take it once per day.

Atorvastatin calcium Lipitor is a white, round film-coated tablet containing atorvastatin calcium. Atorvastatin calcium is a synthetic lipid-lowering agent, which is an inhibitor of 3-hydroxymethylglutaryl-coenzyme A HMG-CoA reductase. It is very slightly soluble in distilled water, pH 7. Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell surface for enhanced uptake and catabolism of LDL. Atorvastatin produces a profound and sustained increase in LDL receptor activity coupled with a beneficial change in the quality of circulating LDL particles. Atorvastatin is effective in reducing LDL in patients with homozygous familial hypercholesterolemia, a population that has not normally responded to lipid-lowering medication.

It is also available as a generic medicine. Tens of millions of people use it, said Ken Sternfeld, a New York-based pharmacist. Since there are many statins, it's important to test patients to find out which is the best one for them, Sternfeld said. He recommends a simple 20 mg lipitor test that can determine which drugs a patient can best metabolize. Atorvastatin, and other statins, work by potentially decreasing the production of cholesterol in the body through blocking the cholesterol-producing enzyme in the liver. Consequently, the amount of cholesterol a fat-like substance that collects in the arteries may be reduced.