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Thiopental is an anaesthetic but has no analgesic action; indeed, it may increase perception of pain. Because thiopental causes myocardial and respiratory depression and has a very narrow margin of safety, it has been largely superseded by non-barbiturates. Etomidate has similar effects on the brain to thiopental, producing anaesthesia but no analgesia. The site of action of etomidate is assumed to be activation of GABA receptors.
Authored by Dr. Shane Harper, PA
